Related Experiment Video
Updated: Aug 14, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
Ultraviolet immunosuppression: mechanisms and consequences
Kaija K Hanneman1, Kevin D Cooper, Elma D Baron
1Department of Dermatology, University Hospitals of Cleveland/Case Western Reserve University, Cleveland, OH 44106, USA.
Abstract:
It is well recognized that exposure to solar radiation has several detrimental consequences, both acute and chronic. The suppression of immune functions remains one of the most intriguing phenomena brought about by ultraviolet (UV) radiation. This concept has challenged experts from various disciplines including dermatology, immunology, and photobiology. Although controversies exist regarding the mechanisms involved, the consensus is that UV immune suppression contributes significantly to the growth of cutaneous malignancies--both melanoma and nonmelanoma skin cancer. It is therefore a critical issue to be addressed in the context of developing and using sun protection strategies.
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