Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Link between obesity and type 2 diabetes.

A Golay1, J Ybarra

  • 1Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, 24 rue Micheli-du-Crest, Switzerland. alain.golay@hcuge.ch

Best Practice & Research. Clinical Endocrinology & Metabolism
|November 29, 2005
PubMed
Summary

Obesity and diabetes are closely linked, with "diabesity" describing their interdependence. Weight loss is hampered by reduced fat oxidation, contributing to energy conservation and persistent obesity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Weight loss maintenance].

Revue medicale suisse·2015
Same author

[How to lose weight effectively and in a sustainable manner: a review of current topics].

Revue medicale suisse·2015
Same author

[Food addiction].

Revue medicale suisse·2015
Same author

[The cure of type 2 diabetes and patient education].

Revue medicale suisse·2015
Same author

[Rehabilitation: a case for obese patients?].

Revue medicale suisse·2014
Same author

[The role of patient education in bariatric surgery].

Revue medicale suisse·2014

Area of Science:

  • Metabolism and Endocrinology
  • Obesity Research
  • Diabetes Pathophysiology

Background:

  • The term "diabesity" highlights the strong link between obesity and diabetes.
  • Progression from obesity to diabetes involves declining insulin secretion and rising insulin resistance.
  • Insulin resistance and impaired insulin secretion are early, progressive features in obese individuals.

Purpose of the Study:

  • To explore the relationship between obesity, insulin resistance, and diabetes.
  • To investigate the role of fat oxidation in weight management and its connection to insulin resistance.

Main Methods:

  • Review of existing literature on obesity, insulin resistance, and type 2 diabetes.
  • Analysis of the physiological mechanisms linking fat accumulation, insulin sensitivity, and energy balance.

Related Experiment Videos

Main Results:

  • Increased fatness, particularly visceral and ectopic fat, correlates with insulin resistance.
  • Reduced capacity for lipid oxidation contributes to intramyocellular lipid accumulation.
  • Defective fat oxidation impairs weight loss by promoting energy conservation.

Conclusions:

  • The interplay between insulin resistance, impaired insulin secretion, and fat metabolism is central to "diabesity."
  • Targeting fat oxidation may be a key strategy for managing obesity and preventing diabetes.