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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Unusual duodenal presentation of leishmaniasis

M L Alvarez-Nebreda1, E Alvarez-Fernández, S Rada

  • 1Geriatrics Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain. alvereznebreda@yahoo.es

Journal of Clinical Pathology
|November 29, 2005
PubMed

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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
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