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A "crackleware" oesophagus.

M Westerterp1, O R C Busch, J J G H M Bergman

  • 1Department of Surgery, Academic Medical Centre/University of Amsterdam, Suite G4-123, Meibergdreef 9, 1105 AZ, The Netherlands. m.westerterp@AMC.UVA.NL

Journal of Clinical Pathology
|November 29, 2005
PubMed
Summary
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A 70-year-old woman presented with excessive keratinization in her mouth and esophagus, a condition termed "crackleware" esophagus, which was associated with squamous cell carcinoma. This localized keratinization, unlike genetic disorders, suggests a non-hereditary cause.

Area of Science:

  • Gastroenterology
  • Oncology
  • Dermatology

Background:

  • Squamous cell carcinoma (SCC) can arise from epithelial tissues.
  • Keratinization is a normal process in some epithelia but abnormal in others.
  • Genetic disorders can cause widespread keratinization.

Observation:

  • A 70-year-old woman exhibited excessive diffuse keratinization of the oral cavity and esophagus.
  • This keratinization was associated with a diagnosis of squamous cell carcinoma.
  • Similar keratinization was absent in the patient's vaginal epithelium.

Findings:

  • The localized keratinization in the esophagus and oral cavity, termed "crackleware" esophagus, is a novel finding.
  • The absence of this keratinization in other non-keratinized epithelia suggests a non-genetic etiology.

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  • The presence of squamous cell carcinoma highlights a potential link between this condition and malignancy.

    • Implications:

    • "Crackleware" esophagus represents a previously undescribed clinical entity.
    • Further research is needed to elucidate the specific causes and mechanisms of this localized keratinization.
    • Understanding this condition may improve early detection and management of esophageal and oral cancers.