Genetic variation in the HSD17B1 gene and risk of prostate cancer
- Peter Kraft 1, Paul Pharoah , Stephen J Chanock , Demetrius Albanes , Laurence N Kolonel , Richard B Hayes , David Altshuler , Gerald Andriole , Christine Berg , Heiner Boeing , Noel P Burtt , Bas Bueno-de-Mesquita , Eugenia E Calle , Howard Cann , Federico Canzian , Yen-Ching Chen , David E Crawford , Alison M Dunning , Heather S Feigelson , Matthew L Freedman , John M Gaziano , Ed Giovannucci , Carlos Alberto Gonzalez , Christopher A Haiman , Goran Hallmans , Brian E Henderson , Joel N Hirschhorn , David J Hunter , Rudolf Kaaks , Timothy Key , Loic Le Marchand , Jing Ma , Kim Overvad , Domenico Palli , Malcolm C Pike , Elio Riboli , Carmen Rodriguez , Wendy V Setiawan , Meir J Stampfer , Daniel O Stram , Gilles Thomas , Michael J Thun , Ruth Travis , Antonia Trichopoulou , Jarmo Virtamo , Sholom Wacholder
- 1Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
- 0Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
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View abstract on PubMed
Summary
This summary is machine-generated.This study found no significant link between HSD17B1 gene variants and prostate cancer risk in most ethnic groups. Some associations were observed in Latinos and Japanese Americans, but require further investigation due to small sample sizes.
Area Of Science
- Genetics
- Oncology
- Epidemiology
Background
- Steroid hormones are implicated in prostate carcinogenesis.
- Previous studies on steroid hormone genes and prostate cancer risk have yielded inconclusive results, often due to limited sample sizes or incomplete genetic variation analysis.
Purpose Of The Study
- To comprehensively investigate the association between the HSD17B1 gene and prostate cancer risk.
- To characterize genetic variation in HSD17B1 and its potential impact on prostate cancer development across diverse ethnic groups.
Main Methods
- Systematic characterization of HSD17B1 genetic variation using targeted resequencing and dense genotyping.
- Selection and genotyping of haplotype-tagging single nucleotide polymorphisms (htSNPs) in a large multiethnic cohort (8,290 cases, 9,367 controls).
- Analysis of associations between HSD17B1 htSNPs, haplotypes, and prostate cancer risk, stratified by ethnicity, age, BMI, and family history.
Main Results
- No significant association was found between HSD17B1 htSNPs or haplotypes and prostate cancer risk or tumor stage in the overall multiethnic sample or in U.S. and European whites.
- No subgroup-specific associations were identified when stratified by age, body mass index, or family history.
- A significant inverse association between one HSD17B1 haplotype and prostate cancer risk was observed in Latinos and Japanese Americans (p < 0.002), though this finding is limited by smaller sample sizes in these groups.
Conclusions
- Germline variants in HSD17B1, as characterized by the studied htSNPs, do not appear to substantially influence prostate cancer risk in U.S. and European whites.
- Evidence of ethnic heterogeneity in HSD17B1 haplotype associations suggests potential ethnic-specific roles, warranting further research in larger, diverse populations.
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