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Updated: Aug 14, 2026

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts
Published on: November 7, 2019
Coronary sinus flow reversal in congestive heart failure detected during biventricular pacing
1Cardiac Electrophysiology, Sacred Heart Hospital, Pensacola Heart Institute, 5151 N. 9th Avenue, Pensacola, FL 32504, USA.
Insights
During left ventricular lead implantation, dye reflux was observed in the coronary sinus. This retrograde flow, linked to elevated right atrial pressure, may negatively impact left ventricular function.
Area of Science:
- Cardiology
- Medical Devices
- Cardiac Electrophysiology
Background:
- Left ventricular lead implantation via the coronary sinus is a standard procedure for cardiac resynchronization therapy.
- Coronary sinus venography is used to visualize the cardiac venous anatomy and guide lead placement.
Observation:
- A retrograde flow of contrast dye from the coronary sinus ostium towards the distal coronary sinus was observed during venography.
- This phenomenon occurred against the normal direction of blood flow within the coronary sinus.
Findings:
- The observed reflux was correlated with elevated right atrial pressure exceeding the pressure within the coronary sinus.
- This pressure gradient appears to drive the retrograde flow of contrast dye.
Implications:
- The retrograde flow may have deleterious effects on left ventricular function.
- Understanding this phenomenon is crucial for optimizing lead implantation techniques and patient outcomes.
Abstract:
This report describes a phenomenon observed during implantation of a left ventricular lead through the coronary sinus. During coronary sinus venography there was reflux of dye from the coronary sinus ostium towards the distal part of the sinus against the anticipated direction of flow. This was correlated to elevation of the right atrial pressure above the pressure within the coronary sinus. A review of data is provided and suggests several deleterious effects of this phenomenon on left ventricular function.
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