[Corneal intra-epithelial neoplasia (CIN). Treatment by combined excision and antimetabolite therapy]

We present two clinical cases of corneal intra-epithelial neoplasia defined histopathologically.

We sought to establish the importance of treatment with Mitomycin-C in two cases of corneal intra-epithelial neoplasia. The differential diagnosis was established based on the evolutionary character of the process, as well as specific histopathological aspects of these entities. In both cases, treatment with Mitomycin-C before, during and after surgery contributed to the decrease in the size of the lesion and to their cure without relapse.