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Updated: Aug 14, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Short and efficient approach towards macrocyclic lactones based on a Sonogashira reaction
Jürgen Krauss1, Doris Unterreitmeier, Christine Neudert
1Department of Pharmacy, Zentrum für Pharmaforschung, LMU Munich, Germany. hjkra@cup.uni-muenchen.de
Abstract:
Polyketide-derived macrolactones like zearalenone (1), zearalane (2) or curvularin (3) display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards this class of natural products by a combination of the Sonogashira and Mitsunobu reactions. The resulting lactone 9 was tested against human cancer cell lines at the NCI.
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