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Related Experiment Videos

Probiotics and allergy.

Elizabeth Furrie1

  • 1Department of Immunology, Ninewells Hospital and Medical School, Dundee, UK. elizabeth.furrie@tuht.scot.nhs.uk

The Proceedings of the Nutrition Society
|November 30, 2005
PubMed
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Probiotic therapy, particularly Lactobacillus rhamnosus GG, shows promise in preventing and managing infant allergies like atopic eczema and cow's milk allergy. However, these benefits have not been observed in older individuals.

Area of Science:

  • Immunology
  • Microbiology
  • Allergology

Background:

  • Allergy results from an exaggerated immune response to environmental or food antigens, often involving IgE-mediated type I hypersensitivity.
  • A skewed T-helper 2 immune response in newborns, potentially due to altered gut microbiota, is implicated in allergy development.
  • Western lifestyle changes may disrupt the crucial early-life microbial colonization necessary for immune balance.

Purpose of the Study:

  • To investigate the efficacy of probiotic therapy in preventing and managing allergic diseases.
  • To explore the role of gut microbiota in immune system development and allergy.
  • To assess the impact of Lactobacillus rhamnosus GG on infant allergies.

Main Methods:

  • Review of studies on probiotic therapy for allergy prevention and management.

Related Experiment Videos

  • Focus on Lactobacillus rhamnosus GG and its effects on allergic conditions.
  • Analysis of outcomes in neonates, infants, and older children/young adults.

    • Main Results:

    • Two studies demonstrated that Lactobacillus rhamnosus GG in neonates led to a long-term reduction in allergy incidence, specifically atopic eczema.
    • Probiotic lactobacilli were effective in managing atopic eczema and cow's milk allergy in infants.
    • Positive results were not replicated in studies involving older children and young adults.

    Conclusions:

    • Probiotic interventions, especially Lactobacillus rhamnosus GG, show significant potential for preventing and treating allergies in early life.
    • The gut microbiome plays a critical role in immune system maturation and allergy prevention.
    • Further research is needed to understand the limitations of probiotic therapy in older age groups.