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Updated: Aug 14, 2026
A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury
Published on: September 13, 2018
Effect of human neural progenitor cells on injured spinal cord
Guang-Hui Xu1, Jin-Zhu Bai, Qin-Lin Cai
1Department of Orthopedics, Zibo Central Hospital, Zibo City 255036, Shandong Province , China.
Objective:
To study whether human neural progenitor cells can differentiate into neural cells in vivo and improve the recovery of injured spinal cord in rats.
Methods:
Human neural progenitor cells were transplanted into the injured spinal cord and the functional recovery of the rats with spinal cord contusion injury was evaluated with Basso-Beattie-Bresnahan (BBB) locomotor scale and motor evoked potentials. Additionally, the differentiation of human neural progenitor cells was shown by immunocytochemistry.
Results:
Human neural progenitor cells developed into functional cells in the injured spinal cord and improved the recovery of injured spinal cord in both locomotor scores and electrophysiological parameters in rats.
Conclusions:
Human neural progenitor cells can treat injured spinal cord, which may provide a new cell source for research of clinical application.
