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New antimicrobials in ophthalmology
Brett A Levinson1, Allan R Rutzen
1Department of Ophthalmology and Visual Sciences, University of Maryland Medical Center, 419 West Redwood Street, Suite 580, Baltimore, MD 21201, USA.
Ophthalmology Clinics of North America
|November 30, 2005
Summary
This review covers the latest antibiotics, antivirals, and antifungals for eye infections. It highlights new fluoroquinolones, oral/topical antifungals, and oral antivirals, with susceptibility data.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Pharmacology
Background:
- Ophthalmic infections require effective antimicrobial and antiviral therapies.
- Emerging resistance necessitates updated treatment strategies.
- Newer antimicrobial and antiviral agents offer potential solutions.
Purpose of the Study:
- To review the most recent advancements in antibiotics, antivirals, and antifungals for ophthalmic applications.
- To present current research on topical antibiotics, focusing on novel fluoroquinolones.
- To summarize data on new oral and topical antifungals and new oral antivirals.
Main Methods:
- Comprehensive literature review of recent scientific publications.
- Focus on research detailing new antimicrobial and antiviral drug classes.
- Inclusion of data on in vitro susceptibilities and minimum inhibitory concentrations.
Main Results:
- Discussion of the latest topical antibiotic research, including advanced fluoroquinolones.
- Presentation of new oral and topical antifungal agents.
- Overview of emerging oral antiviral treatments for ocular conditions.
- Tabulated data comparing in vitro activity and minimum inhibitory concentrations.
Conclusions:
- Newer antimicrobial and antiviral agents show promise for treating ophthalmic infections.
- Understanding in vitro data is crucial for selecting appropriate agents.
- Continued research is needed to combat resistance and optimize therapy.