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The Membrane Protein Data Bank.

P Raman1, V Cherezov, M Caffrey

  • 1Biophysics Program, The Ohio State University, Columbus, Ohio 43210, USA.

Cellular and Molecular Life Sciences : CMLS
|November 30, 2005
PubMed
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The Membrane Protein Data Bank (MPDB) is a comprehensive database for membrane protein structures and functions. It aids researchers by providing searchable data and links to related resources, facilitating new discoveries.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Membrane proteins are crucial biological entities, yet their structural and functional data are dispersed.
  • A unified, accessible resource is needed to consolidate information on integral, anchored, and peripheral membrane proteins.

Purpose of the Study:

  • To introduce the Membrane Protein Data Bank (MPDB) as a centralized, searchable database.
  • To detail the MPDB's data sources, structure determination methods, and search functionalities.
  • To highlight the database's utility in facilitating research on membrane proteins.

Main Methods:

  • Data compilation from the Protein Data Bank, other databases, and scientific literature.
  • Inclusion of structural data derived from X-ray diffraction, electron diffraction, NMR, and cryo-EM.

Related Experiment Videos

  • Development of an online, searchable relational database with extensive query options.

    • Main Results:

    • The MPDB offers a searchable repository of membrane protein structural and functional information.
    • Entries are hyperlinked to relevant resources like PDB, Pfam, and PubMed for comprehensive data access.
    • Weekly updates ensure data synchronicity with the Protein Data Bank.

    Conclusions:

    • The MPDB serves as a valuable resource for researchers studying membrane proteins.
    • Statistical analysis of MPDB data can inform strategies for membrane protein crystallization.
    • Enhanced accessibility to membrane protein data promotes advancements in structural biology and drug discovery.