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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
Published on: December 10, 2010
Improved cellular response of osteoblast cells using recombinant human osteopontin protein produced by Escherichia
1Department of Biochemistry, Inha University College of Medicine, Jung-Gu, 400-712, Incheon, Korea. juhjang@inha.ac.kr
Biotechnology Letters
|November 30, 2005
Abstract:
Osteopontin is a major non-collagenous bone matrix protein secreted into the mineralizing extracellular matrix by osteoblasts during bone development. Recombinant human osteopontin (hOPN) that includes the Arg-Gly-Asp (RGD) cell recognition site was expressed in Escherichia coli and the purified osteopontin increased cell adhesion, proliferation and differentiation of osteoblast cells (p<0.05).
