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Related Experiment Videos

Sildenafil citrate (Viagra) complexes with bivalent ions.

Petr Melnikov1, Alexandre Cuin, Marcos Antonio Contel Secco

  • 1Department of Clinical Surgery, CCBS, UFMS, Cidade Universitária s/n, CEP 79070-900, Campo Grande/MS, Brazil. petrmelnikov@yahoo.com

Journal of Pharmaceutical Sciences
|November 30, 2005
PubMed
Summary

Calcium ions interacting with sildenafil citrate (Viagra) create a new sildenafil base polymorph. Other metal ions like magnesium, zinc, and cadmium also form related crystalline complexes with sildenafil.

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Area of Science:

  • Coordination Chemistry
  • Materials Science
  • Pharmaceutical Chemistry

Background:

  • Sildenafil citrate, commonly known as Viagra, is a widely used medication.
  • Understanding the chemical interactions of drug molecules with metal ions is crucial for drug formulation and stability.
  • Polymorphism in drug substances can significantly impact bioavailability and therapeutic efficacy.

Purpose of the Study:

  • To investigate the interaction of divalent metal ions (Ca(2+), Mg(2+), Zn(2+), Cd(2+)) with sildenafil citrate.
  • To characterize the resulting solid-state forms and their structural properties.
  • To assess the thermal stability of the newly formed metal-sildenafil complexes.

Main Methods:

  • Chemical precipitation reactions between sildenafil citrate and various divalent metal ion solutions.

Related Experiment Videos

  • X-ray crystallography for determining lattice parameters and crystal structures.
  • Thermogravimetric analysis (TGA) for thermal stability assessment.

    • Main Results:

    • Calcium ions induced the precipitation of a novel polymorph of sildenafil base.
    • Magnesium, zinc, and cadmium ions formed structurally related crystalline complexes with sildenafil (Me(2+)C(28)H(34)N(6)O(11)S).
    • The magnesium complex crystallized in an orthorhombic system, while zinc and cadmium complexes exhibited monoclinic distortions. All compounds showed thermal stability up to 175°C.

    Conclusions:

    • Divalent metal ions significantly influence the solid-state form of sildenafil.
    • The formation of new polymorphs and crystalline complexes has implications for sildenafil's chemical behavior.
    • The characterized metal-sildenafil complexes are thermally stable, decomposing into metal carbonates and oxides at elevated temperatures.