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Rapid detection of deletional alpha-thalassemia by an oligonucleotide microarray

Li Zesong1, Guo Ruijun, Zhang Wen

  • 1Shenzhen Yishengtang Biological Products Co. Ltd., Shenzhen, China. lzssc@yahoo.com

American Journal of Hematology
|November 30, 2005
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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...