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Published on: July 24, 2013

Predictors of hypertension and changes of blood pressure in HIV-infected patients

Rodolphe Thiébaut1, Wafaa M El-Sadr, Nina Friis-Møller

  • 1INSERM E0338 epsilont U593, ISPED, Université Victor Segalen Bordeaux 2, Bordeaux, France. rodolphe.thiebaut@isped.u-bordeaux2.fr

Antiviral Therapy
|December 1, 2005
PubMed

Insights

Hypertension risk in HIV patients increases with age, male sex, higher BMI, and baseline blood pressure. Antiretroviral drugs showed no adverse effect, with non-nucleoside reverse transcriptase inhibitors potentially lowering hypertension risk.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Hypertension is a significant concern in individuals with HIV.
  • Understanding predictors of blood pressure changes and hypertension development is crucial for managing cardiovascular risk in this population.

Purpose of the Study:

  • To identify predictors of changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) during follow-up.
  • To assess predictors of hypertension development in HIV-infected individuals.

Main Methods:

  • Longitudinal analysis of blood pressure (BP) changes using mixed-effects models in 17,170 HIV-1-infected patients from the D:A:D study.
  • Cox models were used to assess predictors of hypertension development in 8,984 patients with normal baseline BP.

Main Results:

  • Older age, male sex, higher body mass index (BMI), and use of BP-lowering drugs were associated with increased SBP and DBP.
  • Hypertension developed in 1186 patients (incidence 72.1 per 1000 person-years), with predictors including male sex, higher BMI, older age, higher baseline BP, high total cholesterol, and clinical lipodystrophy.
  • No association was found between exposure to nucleoside reverse transcriptase inhibitors or protease inhibitors and hypertension risk. Exposure to non-nucleoside reverse transcriptase inhibitors (NNRTIs) was associated with a lower risk of hypertension.

Conclusions:

  • Established hypertension risk factors are associated with increased blood pressure in HIV-infected individuals.
  • No independent detrimental effect of antiretroviral drug classes on BP was observed.
  • Non-nucleoside reverse transcriptase inhibitors (NNRTIs) showed a potential protective association against hypertension development.
Abstract

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