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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
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New strategies for CNS repair

M H Tuszynski1

  • 1Department of Neurosciences, Center for Neural Repair, University of California, San Diego, La Jolla, CA 92093-0626, USA. mtuszynski@ucsd.edu

Ernst Schering Research Foundation Workshop
|December 1, 2005
PubMed
Summary

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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