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Related Experiment Videos

Urinary incontinence caused by prazosin.

S P Rachagan1, A Mathews

  • 1Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur.

Singapore Medical Journal
|June 1, 1992
PubMed
Summary

Urinary incontinence is a rare side effect of the antihypertensive drug prazosin in elderly women. This case report suggests an exaggerated drug response in women with pre-existing borderline stress incontinence may cause this issue.

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Area of Science:

  • Gerontology
  • Pharmacology
  • Urology

Background:

  • Urinary incontinence is a prevalent condition among elderly women.
  • Prazosin is a commonly prescribed antihypertensive medication.

Observation:

  • This case report details a rare instance of urinary incontinence secondary to prazosin use.
  • The patient was an elderly woman using prazosin for hypertension.

Findings:

  • Prazosin, an alpha-1 blocker, can potentially induce urinary incontinence.
  • An exaggerated pharmacological response in individuals with borderline stress incontinence is a likely mechanism.

Implications:

  • Clinicians should consider prazosin as a potential cause of new-onset urinary incontinence in elderly women.
  • This highlights the importance of assessing for pre-existing pelvic floor weakness when prescribing alpha-blockers.
  • Further research into the specific mechanisms and patient populations susceptible to this side effect is warranted.

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