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Early detection of progressive renal dysfunction in patients with coronary artery disease

Giorgio Fuiano1, Domenico Mancuso, Ciro Indolfi

  • 1Departments of Nephrology, and Cardiology, University Magna Graecia of Catanzaro, Italy. fuiano@unicz.it

Kidney International
|December 1, 2005
PubMed

Insights

Coronary artery disease (CAD) patients with normal kidney function show reduced renal perfusion and lack of renal reserve, indicating early signs of progressive kidney dysfunction. These findings highlight the importance of monitoring renal health in CAD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Renal Hemodynamics

Background:

  • Renal hemodynamic dysfunction is linked to coronary artery disease (CAD) in chronic renal failure.
  • Limited data exists on renal function in CAD patients with normal glomerular filtration rate (GFR).

Purpose of the Study:

  • To evaluate early renal function abnormalities in CAD patients.
  • To assess the long-term outcome of renal function in CAD patients.

Main Methods:

  • Studied 15 CAD patients with normal renal function and 15 kidney donors (controls).
  • Measured systemic and renal hemodynamics before and after amino acid (AA) infusion.
  • Repeated renal clearances after two years.

Main Results:

  • CAD patients had lower renal plasma flow (RPF) and higher filtration fraction than controls.
  • CAD patients showed no GFR increase post-AA infusion, indicating absent renal functional reserve.
  • After two years, CAD patients experienced significant decreases in GFR and RPF.

Conclusions:

  • Reduced renal perfusion and absent renal functional reserve are early indicators of progressive renal dysfunction in CAD patients with normal GFR.
  • These findings suggest the need for proactive renal monitoring in CAD patients.
Abstract

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