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Updated: Aug 14, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
New fungal metabolite geranylgeranyltransferase inhibitors with antifungal activity
Sheo B Singh1, Rosemarie Kelly, Ziqiang Guan
1Merck Research laboratories, P.O. Box 2000, Rahway, NJ 07065, USA. sheo_singh@merck.com
Abstract:
Geranylgeranyltransferase I (GGTase I) catalyzes the post-translational transfer of lyophilic diterpenoid geranylgeranyl to the cysteine residue of proteins terminating with a CaaX motif such as Rho1p and Cdc42p. It has been shown that GGTase I activity is essential for viability of Saccharomyces cerevisiae and hence its inhibition is a potential antifungal target. From natural product screening, a number of azaphilones including one novel analog were isolated as broad-spectrum inhibitors of GGTase I. Isolation, structure elucidation, GGTase I inhibitory activities and antifungal activities of these compounds are described.
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