[Acute pancreatitis after treatment with sulindac]

Two women, aged 91 and 46 years respectively, developed acute pancreatitis following treatment with sulindac (Clinoril) for five weeks in the one case and four and a half years in the other. The oldest patient became acutely ill. An emergency laparotomy was performed which showed considerable pancreatic edema and typical fat necroses. The other case presented a more protracted course and was not operated. Restitution was remarkably quick in both patients after cessation of the sulindac treatment.