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[Surface active agents in drug forms and biological systems].

István Eros1

  • 1Szegedi Tudományegyetem, Gyógyszertechnológiai Intézet, Szeged, Eötvös u. 6.-6720.

Acta Pharmaceutica Hungarica
|December 2, 2005
PubMed
Summary

Surface active agents, or surfactants, are versatile in pharmaceutical technology, enhancing drug delivery and formulation. Mathematical models reveal key relationships for optimizing drug bioavailability and stability.

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Area of Science:

  • Pharmaceutical Technology
  • Colloid Science
  • Physical Chemistry

Context:

  • Surfactants are crucial in pharmaceutical formulations, acting as traditional additives and in advanced drug delivery systems.
  • Their application spans various dosage forms, including ointments, emulsions, and solubilization systems.
  • Understanding surfactant behavior is key to developing effective pharmaceutical products.

Purpose:

  • To survey the diverse application areas of surface active agents in pharmaceutical technology.
  • To summarize the role of surfactants in traditional additives, modern drug delivery, and biopharmaceutical applications.
  • To present mathematical relationships governing surfactant behavior in formulations.

Summary:

  • The study explores surfactant applications in pharmaceuticals, detailing their use as additives and in drug delivery systems.
  • It establishes mathematical relationships, including exponential and linear functions, between surfactant properties (e.g., contact angle, concentration) and formulation characteristics (e.g., viscosity, stability, drug release).
  • These functions provide a quantitative basis for formulating pharmaceutical compositions with improved bioavailability.

Impact:

  • Provides quantitative insights for optimizing pharmaceutical formulations using surfactants.
  • Facilitates the development of advanced drug delivery systems with enhanced efficacy.
  • Contributes to a deeper understanding of surfactant-colloid interactions in pharmaceutical science.

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