Effective treatment of neuropsychological deficits in Sjögren's syndrome

Primary Sjögren's syndrome (SS) is an autoimmune disorder that can manifest as central nervous system (CNS) dysfunction and include neuropsychological deficits. Given the limited information published on the cognitive deficits associated with SS, a case of SS is reported here. The primary CNS manifestations were dissociative episodes, and objectively measured neuropsychological dysfunction which was most notable in visual-spatial abilities (as measured by the WAIS-R PIQ, WMS-R Visual Memory Index, and Rey Complex Figure) and in left-sided coordination (as assessed by the Lafayette Grooved Pegboard). Clinical symptomatology and cognition improved following therapy with high-dose corticosteroids.