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On the edge: modeling protrusion
1Department of Mathematics and Center for Genetics and Development, University of California, Davis, California 95616, USA. mogilner@math.ucdavis.edu
Current Opinion in Cell Biology
|December 2, 2005
Summary
Understanding cell crawling requires studying actin protrusion. Modern models, including autocatalytic branching and nano-propulsion, are advancing toward a unified theory of actin network dynamics for cell movement.
Area of Science:
- Cell biology
- Biophysics
- Biochemistry
Background:
- Actin-based protrusion drives cell crawling, a fundamental biological process.
- Recent advances in studying actin networks in lamellipodia and Listeria's comet tails enable in vitro and in silico reconstitution.
- Previous models focused on single actin filament dynamics.
Purpose of the Study:
- To review and synthesize modern models of actin network dynamics.
- To elucidate the forces and dynamics within complex actin networks.
- To progress toward a unified model of actin-based protrusion.
Main Methods:
- Analysis of existing theoretical models: tethered ratchet, autocatalytic branching, end-tracking motor action, elastic- and nano- propulsion.
- Comparison of model predictions with recent biophysical data.
- Evaluation of model limitations and interrelationships.
Main Results:
- Modern models provide insights into the dynamics and forces of complex actin networks.
- Specific models like autocatalytic branching and nano-propulsion are key to understanding protrusion.
- Progress is being made in reconciling different models and experimental data.
Conclusions:
- A unified model of actin-based protrusion is becoming achievable.
- Understanding these complex actin dynamics is crucial for cell motility research.
- Further integration of theoretical models and experimental data is needed.