Related Experiment Video
Updated: Aug 14, 2026
Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
Published on: August 31, 2016
Fetal cells in a transcervical cell sample collected at 5 weeks of gestation
Riccardo Cioni1, Cecilia Bussani, Sandra Bucciantini
1Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Careggi University Hospital, Florence, Italy.
Abstract:
Transcervical cell (TCC) sampling is being investigated as a promising method for obtaining fetal cells for prenatal genetic diagnosis. The present case report describes the identification of fetal cells by both fluorescent in situ hybridisation (FISH) and quantitative fluorescent polymerase chain reaction (QF-PCR) analyses in a TCC sample collected by intrauterine lavage at 5 + 0 weeks. This finding underscores the possible relevance of TCC sampling for extremely early prenatal genetic diagnosis.
