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Related Experiment Videos

Sesquiterpenoids from Vernonia cinerea.

Xin Chen1, Zha-Jun Zhan, Jian-Min Yue

  • 1State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201203, P.R. China.

Natural Product Research
|December 2, 2005
PubMed
Summary

A new compound, vernocinolide A, was discovered in Vernonia cinerea, alongside ten known sesquiterpenoids. Nine of these known compounds were isolated from this plant for the first time, expanding our knowledge of its chemical constituents.

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Organic Chemistry

Context:

  • Vernonia cinerea is a plant with a history of traditional medicinal use.
  • The ethyl acetate soluble fraction of Vernonia cinerea was investigated for its chemical components.
  • Sesquiterpenoids are a diverse class of natural products known for various biological activities.

Purpose:

  • To isolate and characterize chemical constituents from Vernonia cinerea.
  • To identify novel compounds and previously unreported compounds from this plant species.
  • To contribute to the understanding of the phytochemical profile of Vernonia cinerea.

Summary:

  • A new sesquiterpenoid, vernocinolide A (1), was isolated and its structure elucidated using spectroscopic methods.

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  • Ten known sesquiterpenoids (2-11) were also identified in the ethyl acetate soluble fraction.
  • Nine of the known sesquiterpenoids were reported from Vernonia cinerea for the first time.

    • Impact:

    • The discovery of vernocinolide A adds to the known repertoire of sesquiterpenoids.
    • This study expands the phytochemical database of Vernonia cinerea.
    • The findings may provide a basis for further research into the biological activities and potential applications of these isolated compounds.