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Venous thrombosis in an ALS population over four years

L B Elman1, A Siderowf, G Houseman

  • 1Penn Neurological Institute, 330 South 9th Street, University of Pennsylvania, Philadelphia, PA 19107, USA. elmanl@uphs.upenn.edu

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
|December 2, 2005
PubMed

Insights

Amyotrophic lateral sclerosis (ALS) patients experience a 2.97% incidence of venous thromboembolism. Immobility is a significant risk factor for developing venous thrombosis in this population.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Epidemiology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
  • Venous thromboembolism (VTE) is a significant concern in various patient populations.
  • Understanding VTE risk in ALS is crucial for patient management.

Purpose of the Study:

  • To determine the incidence of venous thromboembolism (VTE) in patients with Amyotrophic lateral sclerosis (ALS).
  • To identify specific risk factors associated with VTE in the ALS patient cohort.

Main Methods:

  • Retrospective chart review of all ALS patients over a four-year period.
  • Calculation of VTE incidence rates and associated confidence intervals.
  • Statistical analysis to identify significant risk factors, including immobility.

Main Results:

  • A VTE incidence of 2.97% was observed in 438 ALS patients.
  • The annual incidence rate was 33.1 events per 1,000 patients.
  • Immobility showed a significant association with increased risk of venous thrombosis (RR = 4.96).

Conclusions:

  • ALS patients have a higher VTE risk than the general population.
  • Immobility is a key modifiable risk factor for VTE in ALS.
  • Further research into VTE prevention strategies for ALS patients is warranted.

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