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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
T-helper cell type-2 regulation in allergic disease
S N Georas1, J Guo, U De Fanis
1Johns Hopkins Asthma and Allergy Center, Rm. 4B.41 JHAAC 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA. sgeoras@jhmi.edu
The European Respiratory Journal
|December 2, 2005
Summary
Allergic diseases involve an immune system shift toward T-helper cell type 2 (Th2) responses. This review details Th2 cell differentiation and its role in asthma pathogenesis, exploring therapeutic targets.
Area of Science:
- Immunology
- Allergy and Asthma Research
Background:
- Allergic diseases are linked to a T-helper cell type 2 (Th2) immune response.
- Th2 cytokines are key drivers of allergic inflammation in humans and mouse models.
Purpose of the Study:
- To review the role of Th2 cells in asthma.
- To summarize Th2 cell differentiation from naive precursors.
- To explore signaling pathways and transcription factors in Th2 differentiation.
Main Methods:
- Review of existing experimental evidence and studies.
- Analysis of human and mouse model systems.
- Examination of signaling molecules and transcription factors.
Main Results:
- Th2 cell differentiation is crucial in allergic inflammation.
- Understanding Th2 pathways offers therapeutic targets for asthma.
- Genetically modified mouse studies provide insights into allergic diseases.
Conclusions:
- Th2 cell-mediated immunity is central to allergic diseases like asthma.
- Elucidating Th2 signaling pathways is vital for developing new treatments.
- Translational research from mouse models aids in understanding human allergic conditions.
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