Early-onset and late-onset neonatal group B streptococcal disease--United States, 1996-2004

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A Murine Model of Group B Streptococcus Vaginal Colonization
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A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

    MMWR. Morbidity and Mortality Weekly Report
    |December 2, 2005
    PubMed

    Insights

    Revised guidelines for preventing group B streptococcal (GBS) disease in newborns have significantly reduced early-onset GBS infections. However, late-onset GBS disease incidence remained unchanged, necessitating ongoing surveillance.

    Area of Science:

    • Neonatal Health
    • Infectious Disease Epidemiology
    • Public Health Guidelines

    Background:

    • Perinatal invasive group B streptococcal (GBS) disease poses a significant risk to newborns.
    • In 2002, revised guidelines were issued by the CDC, ACOG, and AAP to prevent GBS disease.
    • These guidelines recommended universal GBS screening for pregnant women and intrapartum antimicrobial prophylaxis for carriers.

    Purpose of the Study:

    • To assess the impact of the 2002 guidelines on multistate trends in neonatal GBS disease incidence.
    • To evaluate changes in early-onset and late-onset GBS disease following guideline implementation.

    Main Methods:

    • Analysis of data from the CDC's Active Bacterial Core surveillance (ABCs) system.
    • Inclusion of data from 1996-2004, covering the period before and after the 2002 guideline revisions.
    • Comparison of GBS disease incidence in infants aged 0-6 days (early-onset) and 7-89 days (late-onset).

    Main Results:

    • Incidence of early-onset GBS disease in infants aged 0-6 days decreased by 31% in 2004 compared to 2000-2001.
    • Incidence of late-onset GBS disease in infants aged 7-89 days showed no significant change during the study period (1996-2004).

    Conclusions:

    • The 2002 guidelines have been effective in reducing early-onset neonatal GBS disease.
    • Continued monitoring is essential to track the long-term impact of the guidelines and intrapartum antimicrobial use on neonatal GBS disease trends.

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