Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional polymorphisms in dopamine and serotonin pathway genes.

Ursula M D'Souza1, Ian W Craig

  • 1Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, United Kingdom. spjgumd@iop.kcl.ac.uk

Human Mutation
|December 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP).

Translational psychiatry·2018
Same author

Interaction between the <i>FTO</i> gene, body mass index and depression: meta-analysis of 13701 individuals.

The British journal of psychiatry : the journal of mental science·2017
Same author

Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.

Biological psychiatry·2016
Same author

Molecular genetics research in sub-Saharan Africa: how can the international community help?

The HUGO journal·2016
Same author

Transcriptomics and the mechanisms of antidepressant efficacy.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2015
Same author

Commentary on "A Role for the X Chromosome in Sex Differences in Variability in General Intelligence?" (Johnson et al., 2009).

Perspectives on psychological science : a journal of the Association for Psychological Science·2015
Same journal

Single-Cell and Multiomics Characterization of p21 in Cancer Progression and Therapeutic Sensitivity.

Human mutation·2026
Same journal

COL1A1 and SERPINE1 as Potential Therapeutic Targets in Diabetic Retinopathy: A Study Incorporating RNA Transcriptomics, Single-Cell RNA Sequencing, and Proteomics.

Human mutation·2026
Same journal

Autosomal Dominant Missense <i>DAG1</i> Variant Linked to Mild-Moderate LGMD R16.

Human mutation·2026
Same journal

RETRACTION: "Differential Effects of AKT1(p.E17K) Expression on Human Mammary Luminal Epithelial and Myoepithelial Cells".

Human mutation·2026
Same journal

Diagnostic Yield of Genome Sequencing in an Iranian Exome-Negative Autosomal-Recessive Intellectual Disability Cohort.

Human mutation·2026
Same journal

Exploring the Functional Impact of Individual <i>DDX41</i> Variants With a Fast and Robust Cell-Based Method.

Human mutation·2026
See all related articles

Genetic variations in monoamine neurotransmitter pathways significantly impact human behavior and clinical relevance. This review details functional studies exploring these gene variants and their molecular mechanisms.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Single nucleotide and simple repeat sequence polymorphisms in monoamine neurotransmitter genes are increasingly recognized for their functional importance.
  • These gene variants are linked to human behavioral disorders and traits, highlighting their clinical significance.

Purpose of the Study:

  • To review published functional studies on polymorphisms in monoamine neurotransmitter pathway genes.
  • To explore the molecular, cellular, and neurobiological underpinnings of these gene variants.
  • To discuss their potential behavioral consequences and clinical relevance.

Main Methods:

  • Functional studies examining gene variants at the protein level (ligand/drug binding).
  • Analysis of gene expression at the transcriptional level in cell cultures and postmortem brain tissue.

Related Experiment Videos

  • Molecular approaches identifying transcription factor interactions with polymorphisms.
  • Neuroimaging studies correlating genotype with brain protein availability.
  • Integration of human and animal studies on gene-environment interactions.

    • Main Results:

    • Pharmacological studies reveal effects on protein binding and drug interactions.
    • Gene expression studies demonstrate altered transcription in various tissues.
    • Identification of specific transcription factors interacting with polymorphic regions.
    • Neuroimaging confirms in vivo functional significance by linking genotype to protein levels.
    • Evidence supports gene-environment interactions influencing behavioral outcomes.

    Conclusions:

    • Findings elucidate plausible molecular mechanisms underlying the functional significance of polymorphisms in monoamine neurotransmitter genes.
    • These genetic variations influence behavioral phenotypes through complex molecular pathways.
    • Understanding these mechanisms is crucial for comprehending the genetic basis of behavior and associated disorders.