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Updated: Aug 14, 2026

Porphyrin-Modified Beads for Use as Compensation Controls in Flow Cytometry
Published on: March 24, 2023
5'-Porphyrin-oligonucleotide conjugates: neutral porphyrin-DNA interactions
Milan Balaz1, Jay D Steinkruger, George A Ellestad
1Department of Chemistry, Columbia University, New York, New York 10027, USA. milan.balaz@chem.ox.ac.uk
Abstract:
[chemical reaction: see text]. Incorporation of hydrophilic tetraarylporphyrin phosphoramidites into the 5'-termimus of the DNA as well as noncharged porphyrin-DNA interactions have been studied. Porphyrin-modified oligonucleotides show lower melting temperatures than their unmodified analogues. Single-stranded DNA interacts more strongly with porphyrin and causes more intense chiral disturbance in the porphyrin environment than the corresponding double strand.
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