Study on the metabolism of racemic prolintane and its optically pure enantiomers
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G Rücker1, M Neugebauer, D Zhong
1Pharmazeutisches Institut, Universität Bonn, Germany.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|February 1, 1992
Abstract:
1. Asian and European volunteers were given racemic prolintane, and the metabolites in the 24 h urine were identified and quantified by g.l.c. mass spectroscopy using synthetic reference compounds. 2. R-(+)- and S-(-)-prolintane were synthesized from optically active phenylalanine. The metabolism of the enantiomers differs mainly in the quantitative amounts of metabolites.