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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Five labdane diterpenoids from the seeds of Aframomum zambesiacum
Marguerite Kenmogne1, Elise Prost, Dominique Harakat
1Department of Chemistry, Faculty of Science, University of Dschang, Box 67, Dschang, Cameroon.
Abstract:
Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC(50) value of 4.97 microM.
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