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Updated: Aug 14, 2026

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity
Sergio A Alonso De Diego1, Marta Gutiérrez-Rodríguez, M Jesús Pérez de Vega
1Instituto de Química Médica Juan de la Cierva, 3, 28006 Madrid, Spain.
Abstract:
A suitable solid-phase approach, based on Fmoc/(t)Bu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
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