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Reduced vitamin D in acute stroke.

Kenneth E S Poole1, Nigel Loveridge, Peter J Barker

  • 1Department of Medicine, Addenbrooke's Hospital, Cambridge, UK. kesp2@cam.ac.uk

Stroke
|December 3, 2005
PubMed
Summary

Most acute stroke patients have insufficient vitamin D levels, a condition that may precede stroke and increase fracture risk. Further research is needed to explore vitamin D repletion strategies for post-stroke recovery.

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Area of Science:

  • Neurology
  • Endocrinology
  • Bone Metabolism

Background:

  • Stroke is linked to decreased bone mineral density and increased hip fracture risk.
  • Vitamin D deficiency is common in stroke survivors and associated with hip fractures.
  • Limited data exists on vitamin D levels during the acute phase of stroke.

Purpose of the Study:

  • To investigate serum 25-dihydroxyvitamin D levels in patients with acute stroke.
  • To compare these levels with those of healthy elderly individuals.
  • To assess the prevalence of vitamin D insufficiency in acute stroke.

Main Methods:

  • Serum 25-dihydroxyvitamin D was measured in 44 acute stroke patients.
  • Levels were compared to 96 healthy elderly subjects measured bimonthly for one year.

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  • Seasonal variations were accounted for using statistical Z scores.

    • Main Results:

    • Acute stroke patients had a mean vitamin D Z score of -1.4.
    • 77% of acute stroke patients exhibited insufficient vitamin D levels.
    • Vitamin D insufficiency was observed throughout the year.

    Conclusions:

    • The majority of acute stroke patients present with reduced vitamin D levels.
    • This deficiency may be a pre-existing condition and a potential stroke risk marker.
    • The therapeutic role of vitamin D supplementation in post-stroke musculoskeletal health requires investigation.