[Medical treatment for primary hyperparathyroidism]

Parathyroidectomy is the only option available for the cure of primary hyperparathyroidism (PHPT), which is a common endocrine disorder and often causes secondary osteoporosis. This disease is now recognized as a disorder with few overt manifestations, presenting most often as mild or asymptomatic hypercalcemia. There are accumulating PHPT patients who are unwilling or are unsuitable for surgery. In these patients, bisphosphonate is a most useful candidate as supportive therapy. Calcimimetic agent which modulates the activity of calcium-sensing receptor on the surface of parathyroid cell and suppresses the secretion of parathyroid hormone, would be an effective nonsurgical approach for management of PHPT.