Related Experiment Video
Updated: Aug 14, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
[Experimental comparative study of bioactive composite with polymeric matrix for applications to oculoplastic surgery
Valênio Pérez França1, Ana Rosa Pimentel de Figueiredo, Anilton César Vasconcelos
1Departamento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina, UFMG, Belo Horizonte, MG. valeniop@uai.com.br
Purpose:
To compare two new biomaterials: Composite 10% (Engineering School--Universidade Federal de Minas Gerais-UFMG-Brazil) and Composite 20% (Engineering School--Universidade Federal de Minas Gerais-UFMG-Brazil), with two similar materials as control: Medpor (Porex Surgical Inc.--USA) e Polipore (Homus Com. Ind. Ltda--BRASIL).
Methods:
In vivo randomized experimental double blind study: a transconjunctival approach was performed in both cartilaginous superior orbital walls of 28 rabbits for 56 implants divided into 4 groups: GI: Composite 10%/Medpor; GII: Composite 10%/Polipore; GIII: Composite 20%/Medpor; GIV: Composite 20%/Polipore. The mean rate for implant time of permanence was 19.7 weeks. The Student's t test was used for statistical analysis.
Results:
Revealed similar biocompatibility of all materials and none of the implants was extruded; one Composite 20% had partial exposure. Histomorphometry showed a greater bioactivity of the composites with significantly thicker fibrous encapsulation, with more collagen and fibroblasts, exuberant angiogenesis, and a lower inflammatory cell mean compared to controls. The presence of precipitation of a hydroxycarbonate apatite layer, which acts as an implant-tissue bond was confirmed. Composites presented a smaller tissular invasion index of the pores compared to controls.
Conclusions:
The composites showed a good biocompatibility and some additional advantage over the Medpor and Polipore controls.
