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Updated: Aug 14, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
[Comparative histologic study of implants (magnets) in orbits of female rabbits]
Elcio Roque Kleinpaul1, Harley Edison Amaral Bicas
1Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP. elcioroq@ig.com.br
Purpose:
To evaluate microscopically the signs of inflammatory reaction due to the fixation of an orbitary implant (magnet, covered by gold).
Methods:
An experimental study was performed in 54 adult female rabbits, divided into 3 groups of eighteen with 3 subgroups of 6; an evaluation at 1, 3 and 6 postoperative weeks was performed. An implant (magnet, covered by gold) was fixed in the inferior orbital rim using biologic glue, screw or unabsorbable suture (Mersilene 5.0). The opposite orbits (without implants) represented the control group.
Results:
Microscopic signs of inflammatory reaction due to orbitary fixation of the implant were observed with the use of the three methods (biologic glue, screw or unabsorbable suture) (Mersilene 5.0), until six weeks of the postoperatory period.
Conclusions:
Histopathological signs of inflammatory reaction to the implant and to its orbital fixation were observed up to the sixth week, with cyanoacrylate, screw, or unabsorbable suture (Mersilene 5.0), with prevalence of the chronic inflammatory process and cicatricial fibrosis, without statistically significant difference in most of the cases.
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