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Antiatherosclerotic properties of oral cicaprost in hypercholesterolemic rabbits
M Braun1, M Sarbia, P Kienbaum
1Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, FRG.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
The effects of the orally active prostacyclin mimetic cicaprost on morphologic and functional alterations of rabbit aorta was investigated in experimental hypercholesterolemia. Oral cicaprost resulted in a significantly reduced aortic atheromatous plaque formation and partially prevented hypercholesterolemia-induced impairment of endothelium-dependent relaxations. It is concluded that long-term substitution with PGI2 may beneficially influence the progression of atherosclerosis.