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Updated: Aug 14, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
[Streptococcus agalactiae in pregnant women. Prevalence at the Posadas Hospital]
S Di Bartolomeo1, M Gentile, G Priore
1Seccion Bioquímica Microbiológica, Servicio de Bioquímica, Hospital Nacional Profesor A. Posadas Av. Pte. Illia y Marconi (1684) El Palomar, Pcia. de Buenos Aires, Argentina. sudiba@ciudad.com.ar
Insights
Group B Streptococcus (GBS) carriage in pregnant women was 9.39% at Posadas Hospital. Most GBS isolates were susceptible to penicillin, erythromycin, and clindamycin, with low resistance observed.
Area of Science:
- Microbiology
- Infectious Diseases
- Obstetrics & Gynecology
Context:
- Group B Streptococcus (GBS) is a leading cause of neonatal infections via vertical transmission.
- GBS also causes infections in pregnant women and immunocompromised adults.
- Understanding GBS carriage and resistance patterns in pregnant populations is crucial for infection control.
Purpose:
- To determine the prevalence of GBS carriage among pregnant women attending Posadas Hospital.
- To analyze the antimicrobial susceptibility patterns of GBS isolates to penicillin, erythromycin, and clindamycin.
Summary:
- A study of 1203 pregnant women found a GBS carriage prevalence of 9.39% (113 isolates).
- Antimicrobial susceptibility testing on 87 GBS isolates revealed universal susceptibility to penicillin.
- Two isolates exhibited resistance to erythromycin and clindamycin, indicating a constitutive MLS mechanism.
Impact:
- Highlights the importance of GBS screening in pregnant women.
- Provides data on GBS antimicrobial resistance, particularly relevant for penicillin-allergic individuals.
- Informs clinical management decisions regarding GBS infections and antibiotic choices during pregnancy.
Abstract:
Streptococcus agalactiae (Lancefield group B Streptococcus), is the most frequent microorganism involved in neonatal infections through the mother-fetus vertical transmission. It is also responsible for infections in pregnant women, and adults with underlying diseases. The objective of this work was to know the S. agalactiae carrier prevalence in pregnant women who attended to Posadas Hospital, and to study the susceptibility pattern of the isolates to penicillin, erythromycin and clindamycin. From 1203 pregnant women studied, S. agalactiae was recovered in 113, which means a prevalence of 9.39%. Antimicrobial susceptibility was tested to 87 isolates. All of them were susceptible to penicillin, and only 2 isolates were resistant to erythromycin and clindamycin (constitutive MLS mechanism). We emphasize the importance of knowing these last resistance, in the case of beta-lactam antibiotics allergic women.
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