Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The acromegalic arthropathy.

A Colao1, R Pivonello, R Scarpa

  • 1Section of Endocrinology, Department of Molecular and Clinical Endocrinology, Federico II, University of Naples, Naples, Italy. colao@unina.it

Journal of Endocrinological Investigation
|December 6, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From diabetes to tumor growth: unravelling the impact of glucose-lowering therapies.

Endocrine·2026
Same author

Single-injection hyaluronic acid treatment demonstrates non-inferiority in the relief of symptomatic knee osteoarthritis: A randomized double-blind, multi-center controlled study.

Osteoarthritis and cartilage open·2026
Same author

The management of adrenocortical carcinoma in the era of precision medicine.

Critical reviews in oncology/hematology·2025
Same author

Nutritional assessment and medical dietary therapy for management of obesity in patients with non-dialysis chronic kidney disease: a practical guide for endocrinologist, nutritionists and nephrologists. A consensus statement from the Italian society of endocrinology (SIE), working group of the club nutrition-hormones and metabolism; the Italian society of nutraceuticals (SINut), club ketodiets and nutraceuticals "KetoNut-SINut"; and the Italian society of nephrology (SIN).

Journal of endocrinological investigation·2024
Same author

Long-term pasireotide therapy in acromegaly: extensive real-life experience of a referral center.

Journal of endocrinological investigation·2024
Same author

Ketogenic nutritional therapy (KeNuT)-a multi-step dietary model with meal replacements for the management of obesity and its related metabolic disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)-diet therapies in endocrinology and metabolism.

Journal of endocrinological investigation·2024
Same journal

Correction: Early in, early out: reproductive lifespan timing and cardiometabolic risk in women.

Journal of endocrinological investigation·2026
Same journal

Adult mice are more susceptible to high-fat diet-induced visceral adiposity and insulin resistance than juvenile mice.

Journal of endocrinological investigation·2026
Same journal

Lactobacillus gasseri alleviates type 2 diabetes via modulation of gut microbiota-host metabolic networks.

Journal of endocrinological investigation·2026
Same journal

Rare causes of exogenous Cushing's Syndrome: a challenge for endocrinologists.

Journal of endocrinological investigation·2026
Same journal

Phase angle and triglyceride-glucose index as biomarkers of glycemic control, body composition and cardiovascular risk in adolescents with type 1 diabetes: a cross-sectional study.

Journal of endocrinological investigation·2026
Same journal

4-Methylumbelliferone for type 1 diabetes therapy: evidence for β-cell protection via EGFR/PI3K/Akt signaling.

Journal of endocrinological investigation·2026
See all related articles

Acromegaly causes progressive joint damage, primarily affecting bones and leading to osteoarthritis. Early treatment normalizing growth hormone (GH) and IGF-I levels can reverse arthropathy, but long-term damage is irreversible.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Orthopedics

Background:

  • Acromegaly, a disorder caused by excess growth hormone (GH), has been known for over a century.
  • Disease control criteria for acromegaly are continuously evolving.
  • Arthropathy is a major source of morbidity and disability in acromegaly patients.

Purpose of the Study:

  • To review the evolving understanding of acromegaly.
  • To highlight the characteristic bone and joint alterations in acromegaly.
  • To emphasize the importance of early diagnosis and treatment for arthropathy.

Main Methods:

  • Review of historical and current literature on acromegaly.
  • Analysis of radiographic and clinical features of acromegalic arthropathy.

Related Experiment Videos

  • Discussion of the progression and reversibility of joint damage.

    • Main Results:

    • Bone and joint alterations are characteristic of acromegaly, affecting the axial and appendicular skeleton.
    • Radiographic changes in joints are more prevalent than symptomatic involvement.
    • Acromegalic arthropathy progresses from cartilage hypertrophy to degenerative changes and osteoarthritis.

    Conclusions:

    • Early normalization of GH and IGF-I levels is crucial for reversing acromegalic arthropathy.
    • Untreated acromegaly can lead to irreversible osteo-articular sequelae.
    • Modern criteria necessitate a re-evaluation of disease control in acromegaly.