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Kidney stone disease and risk factors for coronary heart disease

Satoshi Hamano1, Hiroomi Nakatsu, Noriyuki Suzuki

  • 1Department of Urology, Asahi General Hospital, Asahi-city, Chiba, Japan. shammer@d3.dion.ne.jp

International Journal of Urology : Official Journal of the Japanese Urological Association
|December 6, 2005
PubMed

Insights

Coronary heart disease (CHD) risk factors like smoking, hypertension, and high cholesterol are linked to calcium oxalate (CaOX) kidney stones. Managing these risk factors may help prevent CaOX stone formation.

Area of Science:

  • Nephrology
  • Cardiology
  • Epidemiology

Background:

  • Investigated the association between coronary heart disease (CHD) risk factors and calcium oxalate (CaOX) kidney stone formation.
  • Utilized a case-control study design to compare stone formers with a control group.

Purpose of the Study:

  • To determine the impact of common CHD risk factors on the prevalence of CaOX stone disease.
  • To identify specific risk factors that significantly correlate with CaOX stone formation.

Main Methods:

  • Collected data on body mass index (BMI), alcohol consumption, smoking, hypertension, hypercholesterolemia, diabetes mellitus, and hyperuricemia.
  • Analyzed data from 181 CaOX stone formers and 187 controls using univariate and multivariate logistic regression.

Main Results:

  • A history of CHD was more prevalent in CaOX stone formers (3.9%) than in controls (0%, P = 0.007).
  • Smoking habit (OR 4.29), hypertension (OR 3.57), and hypercholesterolemia (OR 2.74) were significant independent predictors of CaOX stone formation in multivariate analysis.
  • BMI did not reach statistical significance in the multivariate model (P = 0.09).

Conclusions:

  • CaOX stone formers exhibit a significant association with several CHD risk factors.
  • Smoking, hypertension, and hypercholesterolemia are key modifiable risk factors linked to CaOX stone disease.
  • These findings suggest potential benefits of managing cardiovascular risk factors for kidney stone prevention.
Abstract

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