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Updated: Aug 2, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Inadvertent epidural infusion of paracetamol in a child
1Anesthèsie pédiatrique, Hôpital Saint Vincent de Paul, Bd de Belfort BP, Lille Cedex, France. courreges.philippe@ghicl.net
Insights
A medication error occurred when paracetamol was inadvertently administered via epidural infusion instead of intravenous, causing headache and vomiting in a pediatric patient. This highlights the need for vigilance in medication administration to prevent such incidents.
Area of Science:
- Anesthesiology
- Pediatric Pain Management
- Medication Safety
Background:
- Lumbar epidural anesthesia was administered to an 11-year-old boy for severe lower limb burn analgesia.
- A dural puncture occurred during the initial epidural catheter placement, necessitating a second attempt.
Observation:
- Postoperatively, the patient received continuous epidural analgesia and intravenous infusions via separate pumps.
- A nurse mistakenly injected paracetamol into the epidural catheter instead of the intravenous line on two separate occasions.
Findings:
- The patient developed headache and vomiting, presumed to be mechanical complications.
- Symptoms resolved with saline, caffeine, and supportive care; neurological examinations remained normal.
- This case represents the first reported instance of paracetamol administration via epidural route.
Implications:
- Medication administration errors, particularly with epidural infusions, may be underreported.
- Enhanced protocols and double-checks are crucial to prevent inadvertent epidural drug administration.
- This incident underscores the importance of distinguishing between intravenous and epidural infusion pumps to ensure patient safety.
Abstract:
An 11-year-old boy underwent lumbar epidural anesthesia under general anesthesia to provide intra- and postoperative analgesia for a severe burn of his lower limb. A dural tap at the L4-L5 space occurred during the epidural approach. A second attempt through the upper intervertebral space was successful. Postoperatively, the boy was given both continuous epidural analgesia and intravenous (i.v.) infusions. These latter were provided using two similar double track pumps. At the 36th postoperative hour a nurse injected paracetamol using inadvertently the epidural instead of the i.v. pump. The mistake was repeated 6 h later. The boy experienced both headache and vomiting. Symptoms seemed to be a mechanical rather than a toxic complication. They disappeared for 48 h under treatment including saline and caffeine. Neurological examinations stayed normal. No sequelae were noted. The frequency of this type of medication incident is probably underestimated. The literature notes a large list of injected drugs, but paracetamol had never been described.
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