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Related Experiment Videos

Transdermal drug delivery: basic principles for the veterinarian.

P C Mills1, S E Cross

  • 1School of Veterinary Science, University of Queensland, Brisbane, Qld 4072, Australia. p.mills@uq.edu.au

Veterinary Journal (London, England : 1997)
|December 6, 2005
PubMed
Summary

Veterinary topical drug delivery requires understanding skin penetration. Extrapolating transdermal pharmacokinetics between species is unreliable, necessitating careful formulation selection to ensure efficacy and safety.

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Area of Science:

  • Veterinary Pharmacology
  • Dermal Drug Delivery
  • Pharmacokinetics

Background:

  • Topical pharmaceutical formulations are increasingly used in veterinary medicine.
  • A concern exists regarding unregistered formulations for intended species.
  • Transdermal drug pharmacokinetics and pharmacodynamics cannot be reliably extrapolated between species.

Purpose of the Study:

  • To review the fundamental principles of transdermal drug penetration.
  • To discuss factors influencing topical drug absorption in veterinary medicine.
  • To highlight the importance of understanding these principles for safe and effective veterinary topical treatments.

Main Methods:

  • Literature review of transdermal drug delivery principles.
  • Analysis of factors affecting drug movement into and through the skin.

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  • Discussion of inter-species, intra-species, and regional variations in skin penetration.

    • Main Results:

    • Skin penetration of topical drugs is governed by basic biophysical principles.
    • Species, individual, and regional skin variations significantly impact transdermal absorption.
    • Simple extrapolation of pharmacokinetic and pharmacodynamic data across species is not scientifically supported.

    Conclusions:

    • A thorough understanding of transdermal drug delivery principles is crucial for veterinary medicine.
    • This knowledge is essential to prevent adverse effects and ensure therapeutic efficacy of topical formulations.
    • Careful consideration of species-specific and individual factors is necessary when selecting and applying topical veterinary drugs.