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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
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Published on: January 7, 2018

Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal

Rosario Martos1, Miguel Valle, Rosario Morales

  • 1Health Center of Pozoblanco, 14400 Pozoblanco, Córdoba, Spain. rosariomartos96@yahoo.es

Metabolism: Clinical and Experimental
|December 6, 2005
PubMed

Insights

In obese children, homocysteine (Hcy) levels were not different overall, but higher in those with hyperinsulinemia. Insulin resistance and leptin predicted Hcy in obese and non-obese children.

Area of Science:

  • Pediatrics
  • Metabolic Disorders
  • Cardiovascular Health

Background:

  • Obesity is a major risk factor for cardiovascular disease (CVD).
  • Elevated homocysteine (Hcy) is linked to CVD in obese adults.
  • The role of Hcy in obese children's CVD risk is unclear.

Purpose of the Study:

  • To investigate total Hcy levels in obese prepubertal children.
  • To assess the association of Hcy with metabolic syndrome, inflammatory markers, and leptin.
  • To identify predictors of Hcy in obese children.

Main Methods:

  • Study included 43 obese and 43 non-obese children (aged 6-9 years).
  • Measurements included insulin, C-reactive protein, leptin, and Hcy.
  • Multivariate regression analysis was used to identify predictive factors.

Main Results:

  • Obese children showed higher insulin, C-reactive protein, and leptin levels.
  • No significant difference in Hcy between obese and non-obese groups.
  • Hcy was significantly higher in hyperinsulinemic obese children.
  • Insulin resistance and leptin independently predicted Hcy in both obese and control groups.

Conclusions:

  • Hyperinsulinemia in obese children is associated with elevated Hcy.
  • Insulin resistance and leptin are key predictors of Hcy in childhood obesity.
  • Increased Hcy, especially in hyperinsulinemic obese children, may contribute to atherosclerosis and CVD risk.

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