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Updated: Aug 14, 2026

Shock Wave Application to Cell Cultures
Published on: April 8, 2014
Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves
Anna R Ciampa1, Alessandra Carcereri de Prati, Ernesto Amelio
1Dipartimento di Scienze Neurologiche e della Visione, Sezione di Chimica Biologica, Università degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy.
Abstract:
Here, we show that extracorporeal shock waves (ESW), at a low energy density value, quickly increase neuronal nitric oxide synthase (nNOS) activity and basal nitric oxide (NO) production in the rat glioma cell line C6. In addition, the treatment of C6 cells with ESW reverts the decrease of nNOS activity and NO production induced by a mixture of lipopolysaccharides (LPS), interferon-gamma (IFN-gamma) plus tumour necrosis factor-alpha (TNF-alpha). Finally, ESW treatment efficiently downregulates NF-kappaB activation and NF-kappaB-dependent gene expression, including inducible NOS and TNF-alpha. The present report suggests a possible molecular mechanism of the anti-inflammatory action of ESW treatment.
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