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Updated: Aug 14, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions
Hua Zhao1, Olarongbe Olubajo, Zhiyan Song
1Chemistry Program, Department of Natural Sciences and Mathematics, Savannah State University, Savannah, GA 31404, USA. zhaoh@savstate.edu
Abstract:
This paper examined the effect of several pyridinium and imidazolium-based ionic liquids (ILs) on the protease stability in aqueous solutions. In general, the enzyme was found quite active at low concentrations of hydrophilic ILs. In aqueous environment, the enzyme was stabilized by the kosmotropic anions (such as CF3COO- and CH3COO-) and chaotropic cations (such as [BuPy]+ and [EMIM]+), but was destabilized by chaotropic anions (such as tosylate and BF4-) and kosmotropic cations (such as [BMIM]+).
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