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Updated: Jul 6, 2026

A 100 KW Class Applied-field Magnetoplasmadynamic Thruster
Published on: December 22, 2018
The battlefield of pluripotency
1Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JQ, United Kingdom. austin.smith@ed.ac.uk
Abstract:
How embryonic stem cells maintain the potential to differentiate into multiple cell lineages is still unclear. In this issue of Cell, Niwa et al. (2005) show that a duel between the transcription factors Oct3/4 and Cdx2 can restrict embryonic stem cells to either embryonic or placental fate. The vulnerability of lineage potential to transcriptional perturbation may reflect an essential feature of pluripotency.
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