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Updated: Aug 14, 2026
Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
Published on: January 22, 2022
Damage to ovarian reserve associated with laparoscopic excision of endometriomas: a quantitative rather than a
Guido Ragni1, Edgardo Somigliana, Francesca Benedetti
1Infertility Unit, Policlinico, Mangiagalli and Regina Elena Hospital, Università Degli Studi di Milano, Milan, Italy.
Objective:
Retrospective studies suggest that laparoscopic excision of endometriomas is associated with a reduced responsiveness to ovarian hyperstimulation. In this study, we prospectively evaluated ovarian response to hyperstimulation in women selected for in vitro fertilization and intracytoplasmic sperm injection cycles who previously underwent laparoscopic enucleation of a monolateral endometrioma.
Study Design:
Operated and contralateral intact ovaries of the same patient were compared in terms of number of follicles, number of oocytes retrieved, fertilization rate, and rate of high-quality embryos.
Results:
Thirty-eight subjects were included. A reduced number of dominant follicles, oocytes, embryos, and high-quality embryos was observed in the operated gonad. The mean percentage of reduction was 60% (95% confidence interval 38-81%), 53% (95% confidence interval 30-75%), 55% (95% confidence interval 28-81%), and 52% (95% confidence interval 17-87%), respectively. Fertilization rate and rate of good-quality embryos were similar.
Conclusion:
Laparoscopic excision of endometriomas is associated with a quantitative but not a qualitative damage to ovarian reserve.
