Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methamphetamine administration produces immunomodulation in mice.

Sang-Whan In1, Eun-Wha Son, Dong-Kwon Rhee

  • 1Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyunggi-do, South Korea.

Journal of Toxicology and Environmental Health. Part A
|December 6, 2005
PubMed
Summary

Methamphetamine (MA) exposure suppressed the immune system in mice. Oral MA reduced antibody production, T and B cell proliferation, and thymus and spleen weights, while enhancing natural killer cell activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of ginseng in aging: Insights into regulatory T cells activation and mitochondrial regulation.

Journal of ginseng research·2025
Same author

Ginseng as a therapeutic target to alleviate gut and brain diseases via microbiome regulation.

Journal of ginseng research·2025
Same author

Intranasal Immunization of Pneumococcal <i>pep27</i> Mutant Attenuates Allergic and Inflammatory Diseases by Upregulating Skin and Mucosal Tregs.

Vaccines·2024
Same author

COVID-19 infection and ginseng: Predictive influenza virus strains and non-predictive COVID-19 vaccine strains.

Journal of ginseng research·2023
Same author

Pep27 Mutant Immunization Inhibits Caspase-14 Expression to Alleviate Inflammatory Bowel Disease via Treg Upregulation.

Microorganisms·2022
Same author

Immunization with a Pneumococcal pep27 Mutant Strain Alleviates Atopic Dermatitis through the Upregulation of Regulatory T-Cell Activity and Epithelial Barrier Function and Suppressing TSLP Expression.

The Journal of investigative dermatology·2022

Area of Science:

  • Immunology
  • Toxicology
  • Pharmacology

Background:

  • Methamphetamine (MA) abuse is a growing global health concern with severe side effects.
  • Understanding the impact of MA on the immune system is crucial for addressing its health consequences.

Purpose of the Study:

  • To investigate the immunomodulating effects of orally administered methamphetamine (MA) in a mouse model.
  • To evaluate the impact of MA on various components of the immune system, including antibody response, natural killer cell activity, lymphocyte populations, and cell proliferation.

Main Methods:

  • Mice were administered MA (5 mg/kg body weight) orally for 14 days.
  • Immune system evaluation included antibody response to sheep red blood cells (SRBC), natural killer (NK) activity, spleen and thymus lymphocyte subpopulations, and splenocyte proliferation assays (Con A, LPS).

Related Experiment Videos

  • Body weight, spleen weight, thymus weight, and colony-forming units (CFU-GM) were also assessed.

    • Main Results:

    • MA treatment led to decreased body weight, spleen weight, and thymus weight.
    • MA altered lymphocyte subpopulations in the thymus, increasing CD4(+) cells while decreasing CD8(+) and CD4(+)CD8(+) cells.
    • MA suppressed antibody production (IgM, IgG), B and T cell proliferation, and interleukin-2 production, but significantly enhanced splenic NK activity.

    Conclusions:

    • Oral methamphetamine exposure generally suppresses the immune system in mice.
    • Despite enhanced NK cell activity, the overall data indicate a net immunosuppressive effect of MA, highlighting potential risks associated with its abuse.